OncoDB.HCC Expression View

Gene name : ENPP2
Ensembl ID ENSG00000136960
Description Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1. [Source:Uniprot/SWISSPROT;Acc:Q13822]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
23 percent with 2 folds change ( 9 up and 3 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 8 from 115638507 bp to 125720260 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 24642 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.34) HK1 (0.39) HK3 (0.95) HK4 (-0.64) HK5 (-1.43) HK7 (0.33) HK9 (0.00) HK11 (2.29) HK12 (1.26) HK13 (0.56) HK14 (0.19) HK15 (-0.14) HK16 (-0.71) HK18 (-0.29) HK19 (0.92) HK20 (1.51) HK21 (-0.12) HK22 (0.01) HK24 (1.99) HK27 (-0.18) HK28 (-0.38) HK29 (0.89) HK31 (-0.46) HK33 (2.23) HK36 (0.25) HK37 (-0.44) HK38 (0.38) HK39 (0.17) HK42 (0.73) HK46 (-0.20) HK47 (0.36) HK49 (0.49) HK62 (-0.31) HK63 (0.00) HK64 (0.83) HK67 (3.33) HK84 (2.62) HK85 (0.00) SF1 (0.53) SF12 (1.08) SF15 (0.19) SF17 (-0.45) SF18 (0.00) SF21 (0.00) SF22 (-0.23) SF23 (-1.09) SF32 (0.62) SF34 (-0.09) SF35 (0.71) SF3 (0.57) SF30 (-0.11) HK2 (0.98) HK23 (1.47) HK41 (0.44) SF4 (-0.50) SF8 (-1.05) SF9 (0.88)