OncoDB.HCC Expression View

Gene name : MYC
Ensembl ID ENSG00000136997
Description Myc proto-oncogene protein (c-Myc) (Transcription factor p64). [Source:Uniprot/SWISSPROT;Acc:P01106]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
59 percent with 2 folds change ( 6 up and 28 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 8 from 123817498 bp to 133822853 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 417226 -- IMAGE clone locate on exon ( tblastx )
812965 -- IMAGE clone locate on exon ( tblastx )
924007 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.96) HK1 (0.37) HK3 (-0.22) HK4 (-0.21) HK5 (-0.02) HK7 (-1.87) HK9 (-1.75) HK11 (-0.54) HK12 (-1.33) HK13 (-1.89) HK14 (-1.42) HK15 (-0.55) HK16 (-0.77) HK18 (1.42) HK19 (-0.54) HK20 (-4.21) HK21 (1.31) HK22 (-1.68) HK24 (-0.86) HK27 (-0.20) HK28 (-1.86) HK29 (-2.23) HK31 (-2.18) HK33 (0.91) HK36 (1.07) HK37 (0.71) HK38 (-0.86) HK39 (-1.85) HK42 (-1.72) HK46 (0.24) HK47 (0.71) HK49 (0.10) HK62 (-1.22) HK63 (-5.46) HK64 (-2.82) HK67 (0.56) HK84 (1.07) HK85 (-1.91) SF1 (-1.66) SF12 (3.23) SF15 (-0.84) SF17 (-2.02) SF18 (-1.21) SF21 (-1.16) SF22 (-0.78) SF23 (-1.32) SF32 (-1.63) SF34 (-2.40) SF35 (-2.05) SF3 (-1.15) SF30 (-1.74) HK2 (0.72) HK23 (-2.54) HK41 (-0.32) SF4 (-1.84) SF8 (0.48) SF9 (1.56)