OncoDB.HCC Expression View

Gene name : HMGA1
Ensembl ID ENSG00000137309
Description High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein-R). [Source:Uniprot/SWISSPROT;Acc:P17096]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
61 percent with 2 folds change ( 29 up and 0 down in 47 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 6 from 29312628 bp to 39321986 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 782811 -- IMAGE clone locate on exon ( blastn )
CH2 (3.12) HK1 (3.67) HK3 (1.74) HK4 (1.91) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (1.77) HK12 (0.74) HK13 (1.28) HK14 (3.48) HK15 (2.38) HK16 (0.84) HK18 (1.46) HK19 (1.84) HK20 (0.01) HK21 (2.48) HK22 (-0.27) HK24 (1.34) HK27 (1.96) HK28 (0.20) HK29 (-0.54) HK31 (1.25) HK33 (1.61) HK36 (0.92) HK37 (2.58) HK38 (1.20) HK39 (1.55) HK42 (1.80) HK46 (1.23) HK47 (1.05) HK49 (0.13) HK62 (0.99) HK63 (-0.24) HK64 (-0.03) HK67 (1.68) HK84 (1.36) HK85 (-0.52) SF1 (2.60) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (-0.03) SF34 (0.48) SF35 (2.46) SF3 (2.67) SF30 (2.28) HK2 (0.57) HK23 (1.19) HK41 (0.59) SF4 (-0.71) SF8 (0.09) SF9 (2.46)