OncoDB.HCC Expression View

Gene name : CASP1
Ensembl ID ENSG00000137752
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit]. [Source:Uniprot/SWISSPROT;Acc:P29466]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 4 up and 16 down in 47 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
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Display nearby genome region Chr 11 from 99401458 bp to 109477368 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 120106 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.28) HK3 (-0.55) HK4 (0.37) HK5 (-0.73) HK7 (-0.32) HK9 (-1.50) HK11 (-0.18) HK12 (-0.63) HK13 (-1.17) HK14 (-2.54) HK15 (-1.06) HK16 (-0.22) HK18 (-0.81) HK19 (-1.52) HK20 (0.03) HK21 (-1.86) HK22 (0.07) HK24 (-0.22) HK27 (-0.50) HK28 (-0.15) HK29 (0.43) HK31 (0.88) HK33 (0.66) HK36 (-1.88) HK37 (-1.60) HK38 (-1.19) HK39 (-0.11) HK42 (0.00) HK46 (-0.21) HK47 (-1.15) HK49 (-0.59) HK62 (0.00) HK63 (0.14) HK64 (0.00) HK67 (0.00) HK84 (0.00) HK85 (-1.44) SF1 (1.09) SF12 (-1.90) SF15 (-1.13) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (-1.46) SF32 (1.60) SF34 (-0.25) SF35 (-0.62) SF3 (-1.48) SF30 (-0.85) HK2 (1.56) HK23 (0.93) HK41 (2.67) SF4 (-0.43) SF8 (-0.44) SF9 (-1.42)