OncoDB.HCC Expression View

Gene name : THBS1
Ensembl ID ENSG00000137801
Description Thrombospondin-1 precursor. [Source:Uniprot/SWISSPROT;Acc:P07996]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
52 percent with 2 folds change ( 1 up and 29 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 15 from 32660572 bp to 42676957 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 429042 -- IMAGE clone locate on exon ( tblastx )
810512 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.12) HK1 (-1.66) HK3 (-2.01) HK4 (-1.22) HK5 (-0.86) HK7 (-0.02) HK9 (-3.44) HK11 (-1.76) HK12 (-0.85) HK13 (-0.81) HK14 (-0.85) HK15 (-0.88) HK16 (-2.63) HK18 (-1.25) HK19 (-1.04) HK20 (-1.75) HK21 (2.27) HK22 (-2.90) HK24 (-1.70) HK27 (-0.21) HK28 (-2.48) HK29 (-1.17) HK31 (-1.58) HK33 (-1.30) HK36 (0.75) HK37 (-1.79) HK38 (-0.87) HK39 (-0.40) HK42 (-2.14) HK46 (-0.49) HK47 (-2.51) HK49 (0.40) HK62 (-0.87) HK63 (-2.90) HK64 (-1.26) HK67 (-0.41) HK84 (0.66) HK85 (-3.13) SF1 (-1.66) SF12 (-0.35) SF15 (-1.13) SF17 (-3.50) SF18 (-2.57) SF21 (-0.82) SF22 (-0.31) SF23 (-2.74) SF32 (-0.77) SF34 (-2.81) SF35 (0.57) SF3 (-0.88) SF30 (-0.86) HK2 (-2.86) HK23 (0.16) HK41 (-2.32) SF4 (-0.83) SF8 (0.44) SF9 (0.25)