OncoDB.HCC Expression View

Gene name : KHK
Ensembl ID ENSG00000138030
Description Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase). [Source:Uniprot/SWISSPROT;Acc:P50053]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
41 percent with 2 folds change ( 4 up and 19 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Yokoyama et al., Proteomics 4:21111 (2004)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 2 from 22163119 bp to 32177144 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 77897 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.19) HK1 (-0.94) HK3 (-1.31) HK4 (0.02) HK5 (0.11) HK7 (0.67) HK9 (-0.01) HK11 (-1.83) HK12 (-0.29) HK13 (-0.33) HK14 (-1.44) HK15 (-1.46) HK16 (0.51) HK18 (-0.99) HK19 (-0.76) HK20 (-0.20) HK21 (-2.15) HK22 (0.75) HK24 (-0.64) HK27 (-2.60) HK28 (1.29) HK29 (0.26) HK31 (1.03) HK33 (-0.06) HK36 (-0.31) HK37 (-1.19) HK38 (-0.79) HK39 (-0.89) HK42 (-1.97) HK46 (0.76) HK47 (-2.31) HK49 (-0.18) HK62 (-0.67) HK63 (-0.55) HK64 (-0.14) HK67 (-0.19) HK84 (-1.57) HK85 (1.18) SF1 (-0.58) SF12 (-0.83) SF15 (-1.62) SF17 (0.68) SF18 (-1.43) SF21 (0.13) SF22 (0.00) SF23 (-0.46) SF32 (1.09) SF34 (0.49) SF35 (-1.81) SF3 (-1.24) SF30 (-2.51) HK2 (0.07) HK23 (-1.23) HK41 (-1.18) SF4 (-1.41) SF8 (-0.88) SF9 (-3.46)