OncoDB.HCC Expression View

Gene name : CYP2C9
Ensembl ID ENSG00000138109
Description Cytochrome P450 2C9 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)- limonene 7-monooxygenase) (CYPIIC9) (P450 PB-1) (P450 MP-4/MP-8) (S- mephenytoin 4-hydroxylase) (P-450MP). [Source:Uniprot/SWISSPROT;Acc:P11712]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
68 percent with 2 folds change ( 11 up and 22 down in 48 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene    
Display nearby genome region Chr 10 from 91688418 bp to 101739137 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 195712 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.48) HK1 (-0.87) HK3 (-3.48) HK4 (0.00) HK5 (0.00) HK7 (-1.30) HK9 (-0.41) HK11 (-0.07) HK12 (-2.02) HK13 (-1.71) HK14 (0.59) HK15 (-3.06) HK16 (1.35) HK18 (-1.94) HK19 (-0.84) HK20 (-2.11) HK21 (-1.73) HK22 (1.53) HK24 (2.91) HK27 (-2.54) HK28 (-0.37) HK29 (-0.14) HK31 (0.84) HK33 (1.23) HK36 (0.84) HK37 (-5.51) HK38 (-1.52) HK39 (-1.55) HK42 (-1.18) HK46 (-0.88) HK47 (0.00) HK49 (-4.77) HK62 (1.27) HK63 (0.00) HK64 (-1.85) HK67 (2.71) HK84 (-2.98) HK85 (1.13) SF1 (3.16) SF12 (-2.33) SF15 (-1.61) SF17 (0.00) SF18 (1.19) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (0.40) SF34 (0.00) SF35 (-1.62) SF3 (0.18) SF30 (1.50) HK2 (-0.89) HK23 (-3.10) HK41 (2.56) SF4 (0.85) SF8 (-1.56) SF9 (-1.70)