OncoDB.HCC Expression View

Gene name : CYP2C8
Ensembl ID ENSG00000138115
Description Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase). [Source:Uniprot/SWISSPROT;Acc:P10632]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 9 up and 18 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 10 from 91786520 bp to 101819244 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 246619 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.25) HK3 (-3.26) HK4 (-0.75) HK5 (0.08) HK7 (2.00) HK9 (1.45) HK11 (-0.63) HK12 (-1.56) HK13 (0.52) HK14 (-1.56) HK15 (-2.69) HK16 (0.99) HK18 (-2.37) HK19 (0.75) HK20 (-0.89) HK21 (-1.74) HK22 (2.02) HK24 (0.84) HK27 (-1.49) HK28 (0.45) HK29 (0.45) HK31 (-0.37) HK33 (0.91) HK36 (1.07) HK37 (-1.01) HK38 (-0.58) HK39 (0.35) HK42 (0.47) HK46 (-2.99) HK47 (-7.34) HK49 (0.33) HK62 (-0.14) HK63 (-0.89) HK64 (-1.89) HK67 (-0.65) HK84 (-0.10) HK85 (0.93) SF1 (4.05) SF12 (-3.68) SF15 (-4.09) SF17 (-0.39) SF18 (0.00) SF21 (0.42) SF22 (0.00) SF23 (-3.88) SF32 (1.78) SF34 (2.86) SF35 (-1.17) SF3 (0.75) SF30 (2.60) HK2 (-0.04) HK23 (-2.85) HK41 (3.02) SF4 (0.07) SF8 (-1.65) SF9 (-2.43)