OncoDB.HCC Expression View

Gene name : RBP4
Ensembl ID ENSG00000138207
Description Plasma retinol-binding protein precursor (PRBP) (RBP) [Contains: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol- binding protein(1-176)]. [Source:Uniprot/SWISSPROT;Acc:P02753]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 5 up and 23 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 10 from 90341434 bp to 100351491 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 85805 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.10) HK1 (-1.14) HK3 (-1.95) HK4 (-0.19) HK5 (-1.79) HK7 (-0.87) HK9 (-7.61) HK11 (0.02) HK12 (-0.85) HK13 (1.15) HK14 (-1.14) HK15 (-0.13) HK16 (-0.86) HK18 (-1.34) HK19 (0.07) HK20 (-1.06) HK21 (-1.73) HK22 (1.62) HK24 (0.29) HK27 (-2.73) HK28 (0.92) HK29 (-0.61) HK31 (0.37) HK33 (0.11) HK36 (0.83) HK37 (-0.38) HK38 (0.13) HK39 (-2.03) HK42 (-2.68) HK46 (-0.98) HK47 (-1.59) HK49 (1.55) HK62 (-1.58) HK63 (-1.14) HK64 (-1.12) HK67 (-1.10) HK84 (-0.20) HK85 (1.87) SF1 (0.19) SF12 (-1.25) SF15 (0.46) SF17 (0.63) SF18 (0.00) SF21 (0.15) SF22 (0.31) SF23 (0.69) SF32 (-1.59) SF34 (1.44) SF35 (-2.54) SF3 (0.46) SF30 (-1.89) HK2 (-1.27) HK23 (-1.54) HK41 (0.31) SF4 (-0.00) SF8 (-1.17) SF9 (-0.95)