OncoDB.HCC Expression View

Gene name : LGR5
Ensembl ID ENSG00000139292
Description Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67). [Source:Uniprot/SWISSPROT;Acc:O75473]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
26 percent with 2 folds change ( 14 up and 1 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 12 from 65120031 bp to 75264781 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 796624 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.45) HK1 (0.78) HK3 (0.02) HK4 (4.22) HK5 (2.36) HK7 (0.04) HK9 (1.21) HK11 (-0.24) HK12 (0.68) HK13 (1.30) HK14 (0.83) HK15 (0.52) HK16 (1.71) HK18 (-0.24) HK19 (1.42) HK20 (0.82) HK21 (-0.07) HK22 (0.68) HK24 (-0.36) HK27 (0.89) HK28 (-0.19) HK29 (0.26) HK31 (-0.83) HK33 (0.59) HK36 (0.91) HK37 (0.66) HK38 (0.42) HK39 (0.16) HK42 (0.63) HK46 (1.03) HK47 (1.97) HK49 (0.15) HK62 (0.41) HK63 (1.10) HK64 (1.14) HK67 (0.38) HK84 (0.44) HK85 (1.64) SF1 (0.68) SF12 (0.43) SF15 (-0.07) SF17 (0.43) SF18 (-0.64) SF21 (-1.63) SF22 (0.28) SF23 (-0.88) SF32 (0.06) SF34 (0.06) SF35 (0.74) SF3 (-0.34) SF30 (0.38) HK2 (1.36) HK23 (-0.14) HK41 (0.54) SF4 (0.27) SF8 (1.26) SF9 (0.11)