OncoDB.HCC Expression View

Gene name : RB1
Ensembl ID ENSG00000139687
Description Retinoblastoma-associated protein (PP110) (P105-RB) (RB). [Source:Uniprot/SWISSPROT;Acc:P06400]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
16 percent with 2 folds change ( 5 up and 3 down in 50 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up/down     Method -- QPCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 13 from 42775912 bp to 52954123 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 487777 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.68) HK1 (0.92) HK3 (0.08) HK4 (0.00) HK5 (1.17) HK7 (0.09) HK9 (-1.05) HK11 (0.00) HK12 (0.00) HK13 (0.00) HK14 (-0.54) HK15 (0.00) HK16 (0.00) HK18 (0.98) HK19 (1.01) HK20 (-0.50) HK21 (0.19) HK22 (0.29) HK24 (-0.51) HK27 (0.41) HK28 (0.07) HK29 (1.03) HK31 (-0.90) HK33 (-0.39) HK36 (0.22) HK37 (-0.06) HK38 (-0.05) HK39 (-0.00) HK42 (-0.25) HK46 (0.36) HK47 (0.37) HK49 (0.45) HK62 (0.26) HK63 (-1.39) HK64 (-0.62) HK67 (-0.33) HK84 (-0.94) HK85 (-1.05) SF1 (0.00) SF12 (0.72) SF15 (0.51) SF17 (0.81) SF18 (0.12) SF21 (0.91) SF22 (1.30) SF23 (-0.08) SF32 (-0.11) SF34 (0.25) SF35 (-0.18) SF3 (-0.38) SF30 (0.24) HK2 (0.70) HK23 (-0.22) HK41 (0.04) SF4 (1.23) SF8 (0.50) SF9 (0.59)