OncoDB.HCC Expression View

Gene name : TP53
Ensembl ID ENSG00000141510
Description Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13). [Source:Uniprot/SWISSPROT;Acc:P04637]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
12 percent with 2 folds change ( 4 up and 3 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence other     Method -- IHC, Western, Mutation, Methylation    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 17 from 2512464 bp to 12531642 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 24415 -- IMAGE clone locate on exon ( tblastx )
236338 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.38) HK1 (0.01) HK3 (0.71) HK4 (-1.19) HK5 (-0.17) HK7 (0.00) HK9 (0.73) HK11 (0.46) HK12 (0.09) HK13 (0.02) HK14 (0.38) HK15 (0.56) HK16 (0.75) HK18 (-0.41) HK19 (-0.95) HK20 (-0.01) HK21 (0.77) HK22 (0.67) HK24 (0.20) HK27 (0.12) HK28 (-1.55) HK29 (-0.52) HK31 (-1.41) HK33 (0.35) HK36 (0.08) HK37 (0.68) HK38 (-0.01) HK39 (-0.06) HK42 (0.22) HK46 (0.58) HK47 (0.72) HK49 (0.48) HK62 (-0.93) HK63 (0.39) HK64 (-0.53) HK67 (0.24) HK84 (1.11) HK85 (-0.05) SF1 (-0.48) SF12 (1.16) SF15 (0.75) SF17 (-0.10) SF18 (0.97) SF21 (0.46) SF22 (-0.21) SF23 (0.00) SF32 (-0.29) SF34 (-0.09) SF35 (-0.53) SF3 (0.19) SF30 (0.02) HK2 (1.03) HK23 (0.04) HK41 (0.74) SF4 (0.69) SF8 (0.94) SF9 (-0.35)