OncoDB.HCC Expression View

Gene name : SMAD4
Ensembl ID ENSG00000141646
Description Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4). [Source:Uniprot/SWISSPROT;Acc:Q13485]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
12 percent with 2 folds change ( 4 up and 3 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, Mutation    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 18 from 41810611 bp to 51860142 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 23275 -- IMAGE clone locate on exon ( tblastx )
788421 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.07) HK1 (0.10) HK3 (0.77) HK4 (0.28) HK5 (-1.22) HK7 (1.55) HK9 (0.18) HK11 (0.67) HK12 (-0.57) HK13 (0.70) HK14 (0.56) HK15 (-0.09) HK16 (0.08) HK18 (-0.09) HK19 (0.03) HK20 (0.43) HK21 (0.45) HK22 (0.04) HK24 (0.03) HK27 (0.09) HK28 (-0.07) HK29 (0.23) HK31 (0.36) HK33 (-0.14) HK36 (0.32) HK37 (0.45) HK38 (0.13) HK39 (-0.28) HK42 (0.00) HK46 (0.26) HK47 (0.10) HK49 (0.69) HK62 (-0.36) HK63 (0.96) HK64 (0.57) HK67 (-0.29) HK84 (-1.85) HK85 (-0.61) SF1 (-0.94) SF12 (0.22) SF15 (0.23) SF17 (0.06) SF18 (-1.03) SF21 (0.54) SF22 (-0.39) SF23 (1.23) SF32 (-0.40) SF34 (-0.15) SF35 (-0.30) SF3 (0.20) SF30 (1.05) HK2 (-0.23) HK23 (-0.91) HK41 (0.53) SF4 (-0.25) SF8 (0.10) SF9 (0.27)