OncoDB.HCC Expression View

Gene name : ERBB2
Ensembl ID ENSG00000141736
Description Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19) (CD340 antigen). [Source:Uniprot/SWISSPROT;Acc:P04626]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
29 percent with 2 folds change ( 2 up and 15 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 17 from 30104766 bp to 40138441 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 141768 -- IMAGE clone locate on exon ( tblastx )
365147 -- IMAGE clone locate on exon ( tblastx )
756253 -- IMAGE clone locate on exon ( tblastx )
783729 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.85) HK1 (-0.30) HK3 (-0.78) HK4 (-0.95) HK5 (-1.11) HK7 (0.77) HK9 (0.36) HK11 (-0.76) HK12 (-0.57) HK13 (-0.88) HK14 (-0.24) HK15 (-0.34) HK16 (0.74) HK18 (-0.87) HK19 (0.84) HK20 (-1.49) HK21 (0.63) HK22 (-0.79) HK24 (0.07) HK27 (-1.58) HK28 (0.40) HK29 (0.38) HK31 (0.50) HK33 (0.02) HK36 (-0.97) HK37 (-0.70) HK38 (-2.22) HK39 (-1.27) HK42 (-1.60) HK46 (0.05) HK47 (-1.68) HK49 (-0.56) HK62 (0.52) HK63 (-0.64) HK64 (-1.13) HK67 (0.20) HK84 (-0.12) HK85 (-0.02) SF1 (1.01) SF12 (-1.51) SF15 (-1.99) SF17 (-2.19) SF18 (-1.94) SF21 (-0.65) SF22 (-0.93) SF23 (-0.34) SF32 (0.65) SF34 (0.63) SF35 (-0.90) SF3 (-1.02) SF30 (-1.20) HK2 (1.99) HK23 (0.72) HK41 (-1.09) SF4 (-0.78) SF8 (0.06) SF9 (-0.27)