OncoDB.HCC Expression View

Gene name : CYR61
Ensembl ID ENSG00000142871
Description Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1). [Source:Uniprot/SWISSPROT;Acc:O00622]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
75 percent with 2 folds change ( 1 up and 42 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 1 from 80819005 bp to 90822233 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 378488 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.39) HK1 (-1.81) HK3 (-1.98) HK4 (-4.05) HK5 (-1.38) HK7 (-0.57) HK9 (-2.66) HK11 (-0.26) HK12 (-2.52) HK13 (-2.23) HK14 (-1.47) HK15 (-0.50) HK16 (-1.04) HK18 (-2.89) HK19 (-3.93) HK20 (-4.16) HK21 (0.75) HK22 (-2.30) HK24 (-1.41) HK27 (1.15) HK28 (-1.67) HK29 (-2.50) HK31 (-3.11) HK33 (-0.60) HK36 (-1.39) HK37 (-2.80) HK38 (-2.90) HK39 (-0.13) HK42 (-1.12) HK46 (-4.05) HK47 (-3.77) HK49 (-0.08) HK62 (-2.04) HK63 (-2.68) HK64 (-4.40) HK67 (-3.15) HK84 (-3.50) HK85 (-2.92) SF1 (-2.50) SF12 (-2.64) SF15 (-1.73) SF17 (-3.67) SF18 (-2.70) SF21 (0.08) SF22 (-1.09) SF23 (-2.35) SF32 (-2.36) SF34 (-0.07) SF35 (-0.85) SF3 (-0.41) SF30 (-2.17) HK2 (-1.96) HK23 (-2.25) HK41 (-3.44) SF4 (-0.44) SF8 (-0.81) SF9 (-0.44)