OncoDB.HCC Expression View

Gene name : RGS5
Ensembl ID ENSG00000143248
Description Regulator of G-protein signaling 5 (RGS5). [Source:Uniprot/SWISSPROT;Acc:O15539]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
66 percent with 2 folds change ( 37 up and 1 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 1 from 156378718 bp to 166454050 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 341805 -- IMAGE clone locate on exon ( blastn )
271038 -- IMAGE clone locate on exon ( tblastx )
853809 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.63) HK1 (1.82) HK3 (2.22) HK4 (-0.36) HK5 (3.20) HK7 (1.22) HK9 (0.78) HK11 (1.78) HK12 (1.89) HK13 (1.28) HK14 (-1.17) HK15 (1.84) HK16 (0.99) HK18 (1.04) HK19 (1.68) HK20 (0.94) HK21 (0.60) HK22 (1.89) HK24 (0.97) HK27 (1.80) HK28 (0.90) HK29 (1.92) HK31 (1.99) HK33 (2.15) HK36 (3.04) HK37 (1.01) HK38 (1.55) HK39 (0.17) HK42 (0.44) HK46 (1.16) HK47 (0.52) HK49 (3.84) HK62 (2.01) HK63 (-0.74) HK64 (1.15) HK67 (2.03) HK84 (0.78) HK85 (0.79) SF1 (0.70) SF12 (3.96) SF15 (2.38) SF17 (1.93) SF18 (1.69) SF21 (2.40) SF22 (2.14) SF23 (-0.66) SF32 (1.98) SF34 (3.34) SF35 (0.60) SF3 (0.46) SF30 (-0.26) HK2 (1.45) HK23 (1.82) HK41 (1.48) SF4 (1.42) SF8 (3.55) SF9 (1.21)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).