OncoDB.HCC Expression View

Gene name : MCL1
Ensembl ID ENSG00000143384
Description Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2- related protein EAT/mcl1) (mcl1/EAT). [Source:Uniprot/SWISSPROT;Acc:Q07820]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
40 percent with 2 folds change ( 1 up and 20 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 1 from 143813661 bp to 153818760 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 843287 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.61) HK1 (-0.08) HK3 (-0.23) HK4 (-0.11) HK5 (-1.04) HK7 (-0.06) HK9 (-1.59) HK11 (-0.24) HK12 (-0.81) HK13 (-0.07) HK14 (-0.43) HK15 (0.11) HK16 (0.23) HK18 (-0.14) HK19 (-1.10) HK20 (-0.31) HK21 (0.49) HK22 (-0.79) HK24 (-0.67) HK27 (-0.59) HK28 (-1.64) HK29 (-0.53) HK31 (0.01) HK33 (-0.42) HK36 (-0.45) HK37 (-0.68) HK38 (-0.08) HK39 (-0.83) HK42 (-1.87) HK46 (-1.06) HK47 (0.00) HK49 (0.87) HK62 (-2.60) HK63 (-0.66) HK64 (-0.54) HK67 (-0.75) HK84 (-1.40) HK85 (0.00) SF1 (-1.83) SF12 (-2.08) SF15 (1.23) SF17 (-1.09) SF18 (0.00) SF21 (-1.23) SF22 (-1.68) SF23 (0.00) SF32 (-0.76) SF34 (-1.25) SF35 (-1.52) SF3 (-1.07) SF30 (0.79) HK2 (-0.23) HK23 (-2.10) HK41 (-0.87) SF4 (-1.15) SF8 (0.00) SF9 (-1.14)