OncoDB.HCC Expression View

Gene name : ALDH1L1
Ensembl ID ENSG00000144908
Description 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1). [Source:Uniprot/SWISSPROT;Acc:O75891]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
65 percent with 2 folds change ( 4 up and 32 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 3 from 122305102 bp to 132382719 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 68061 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.79) HK1 (-0.91) HK3 (-1.30) HK4 (-3.35) HK5 (0.82) HK7 (0.93) HK9 (-2.44) HK11 (-3.32) HK12 (-2.95) HK13 (-1.41) HK14 (-3.90) HK15 (-2.18) HK16 (0.00) HK18 (-0.18) HK19 (-1.51) HK20 (-3.39) HK21 (-1.55) HK22 (-1.40) HK24 (-0.28) HK27 (-0.97) HK28 (-1.15) HK29 (0.04) HK31 (0.23) HK33 (2.75) HK36 (0.64) HK37 (-3.23) HK38 (-4.10) HK39 (-5.56) HK42 (-0.42) HK46 (0.31) HK47 (-3.17) HK49 (-5.78) HK62 (0.33) HK63 (-2.50) HK64 (-2.52) HK67 (-1.69) HK84 (-1.74) HK85 (0.60) SF1 (0.55) SF12 (-2.70) SF15 (-6.51) SF17 (1.31) SF18 (-0.90) SF21 (-0.39) SF22 (3.84) SF23 (-1.95) SF32 (-4.67) SF34 (-1.59) SF35 (-1.52) SF3 (-2.42) SF30 (0.00) HK2 (-2.05) HK23 (-0.53) HK41 (3.06) SF4 (-1.33) SF8 (0.90) SF9 (-4.79)