OncoDB.HCC Expression View

Gene name : PLAC8
Ensembl ID ENSG00000145287
Description Placenta-specific gene 8 protein (Protein C15). [Source:Uniprot/SWISSPROT;Acc:Q9NZF1]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
94 percent with 2 folds change ( 0 up and 50 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 79230239 bp to 89254935 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 491644 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.81) HK1 (-3.72) HK3 (-2.93) HK4 (-3.94) HK5 (-3.62) HK7 (0.00) HK9 (-5.26) HK11 (-2.10) HK12 (-1.68) HK13 (-3.73) HK14 (-3.86) HK15 (-2.89) HK16 (-1.82) HK18 (-1.56) HK19 (-1.59) HK20 (-1.31) HK21 (-1.28) HK22 (-1.22) HK24 (-3.75) HK27 (-3.20) HK28 (-2.23) HK29 (-1.09) HK31 (-2.79) HK33 (-3.53) HK36 (-3.57) HK37 (0.00) HK38 (-3.04) HK39 (-2.62) HK42 (-2.11) HK46 (-2.91) HK47 (-3.22) HK49 (-3.53) HK62 (-1.28) HK63 (-3.10) HK64 (-4.52) HK67 (-1.52) HK84 (-3.38) HK85 (-4.15) SF1 (0.00) SF12 (-2.62) SF15 (-2.51) SF17 (-2.66) SF18 (-3.17) SF21 (0.46) SF22 (-3.64) SF23 (-1.14) SF32 (-3.41) SF34 (0.19) SF35 (-2.55) SF3 (-3.76) SF30 (-3.21) HK2 (-4.05) HK23 (-2.79) HK41 (0.00) SF4 (0.39) SF8 (-2.90) SF9 (-1.72)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).