OncoDB.HCC Expression View

Gene name : BHMT
Ensembl ID ENSG00000145692
Description Betaine--homocysteine S-methyltransferase (EC 2.1.1.5). [Source:Uniprot/SWISSPROT;Acc:Q93088]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
70 percent with 2 folds change ( 14 up and 25 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 5 from 73443358 bp to 83463864 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 77636 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.80) HK1 (-1.82) HK3 (0.37) HK4 (-0.65) HK5 (-1.56) HK7 (-1.29) HK9 (2.15) HK11 (-1.73) HK12 (-2.22) HK13 (-2.79) HK14 (-2.46) HK15 (-1.68) HK16 (2.04) HK18 (-1.35) HK19 (-0.44) HK20 (-0.90) HK21 (-2.23) HK22 (-0.96) HK24 (0.81) HK27 (-1.40) HK28 (-2.07) HK29 (1.83) HK31 (2.22) HK33 (2.20) HK36 (-2.43) HK37 (-2.70) HK38 (-2.23) HK39 (-2.00) HK42 (-0.57) HK46 (-0.37) HK47 (-0.74) HK49 (-1.00) HK62 (0.00) HK63 (-0.75) HK64 (-1.02) HK67 (0.68) HK84 (0.36) HK85 (4.07) SF1 (1.69) SF12 (-0.98) SF15 (-2.52) SF17 (3.73) SF18 (-1.07) SF21 (5.43) SF22 (1.73) SF23 (-1.21) SF32 (1.41) SF34 (-0.99) SF35 (-2.35) SF3 (0.00) SF30 (-3.18) HK2 (2.51) HK23 (2.37) HK41 (3.53) SF4 (-1.45) SF8 (-2.94) SF9 (-1.47)