OncoDB.HCC Expression View

Gene name : CRHBP
Ensembl ID ENSG00000145708
Description Corticotropin-releasing factor-binding protein precursor (CRF-binding protein) (CRF-BP) (Corticotropin-releasing hormone-binding protein) (CRH-BP). [Source:Uniprot/SWISSPROT;Acc:P24387]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
73 percent with 2 folds change ( 1 up and 41 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA microarray - - Shirota et al., Hepatology 33:832 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 5 from 71284436 bp to 81301055 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 266336 -- IMAGE clone locate on exon ( blastn )
701231 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.03) HK1 (-2.66) HK3 (-1.27) HK4 (-3.21) HK5 (-4.11) HK7 (-2.56) HK9 (-4.68) HK11 (-0.47) HK12 (-1.97) HK13 (-2.45) HK14 (-2.13) HK15 (-1.84) HK16 (-0.94) HK18 (-2.53) HK19 (-0.84) HK20 (-1.98) HK21 (-0.17) HK22 (-0.25) HK24 (-2.08) HK27 (-0.58) HK28 (-0.99) HK29 (-1.26) HK31 (-1.67) HK33 (-2.63) HK36 (-1.63) HK37 (-2.75) HK38 (-2.85) HK39 (-0.99) HK42 (-0.45) HK46 (-1.99) HK47 (-2.37) HK49 (-1.05) HK62 (-0.86) HK63 (-6.54) HK64 (-2.19) HK67 (-1.72) HK84 (-6.08) HK85 (-2.27) SF1 (-2.04) SF12 (-1.78) SF15 (1.11) SF17 (-1.30) SF18 (-2.35) SF21 (0.00) SF22 (-2.03) SF23 (-0.48) SF32 (-3.19) SF34 (-1.09) SF35 (-0.72) SF3 (-2.97) SF30 (-1.67) HK2 (-3.27) HK23 (-1.99) HK41 (-2.25) SF4 (-0.09) SF8 (-1.85) SF9 (-0.76)