OncoDB.HCC Expression View

Gene name : MUT
Ensembl ID ENSG00000146085
Description Methylmalonyl-CoA mutase, mitochondrial precursor (EC 5.4.99.2) (MCM) (Methylmalonyl-CoA isomerase). [Source:Uniprot/SWISSPROT;Acc:P22033]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
30 percent with 2 folds change ( 0 up and 17 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 6 from 44506958 bp to 54538811 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 969748 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.63) HK1 (-1.45) HK3 (-0.83) HK4 (-0.18) HK5 (-2.01) HK7 (-1.40) HK9 (0.12) HK11 (-1.14) HK12 (-0.50) HK13 (0.70) HK14 (-0.73) HK15 (-0.95) HK16 (0.01) HK18 (-1.64) HK19 (-0.26) HK20 (0.53) HK21 (-1.56) HK22 (0.33) HK24 (-0.05) HK27 (-1.48) HK28 (-0.03) HK29 (-0.43) HK31 (0.16) HK33 (0.41) HK36 (-0.62) HK37 (-1.32) HK38 (0.58) HK39 (-1.64) HK42 (-0.27) HK46 (-1.51) HK47 (0.31) HK49 (-0.83) HK62 (0.00) HK63 (0.65) HK64 (-0.47) HK67 (0.51) HK84 (-1.03) HK85 (-0.15) SF1 (-1.52) SF12 (-1.46) SF15 (-0.93) SF17 (0.02) SF18 (-2.48) SF21 (-0.18) SF22 (-0.80) SF23 (-0.27) SF32 (0.74) SF34 (0.55) SF35 (-2.25) SF3 (-0.82) SF30 (-1.56) HK2 (-0.75) HK23 (0.10) HK41 (-0.15) SF4 (-0.88) SF8 (-0.85) SF9 (-2.99)