OncoDB.HCC Expression View

Gene name : PNRC1
Ensembl ID ENSG00000146278
Description Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (B4-2 protein). [Source:Uniprot/SWISSPROT;Acc:Q12796]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
43 percent with 2 folds change ( 0 up and 24 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 6 from 84847189 bp to 94851598 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 857002 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.02) HK1 (-1.06) HK3 (-0.25) HK4 (-0.71) HK5 (-3.30) HK7 (-1.89) HK9 (-3.42) HK11 (-0.33) HK12 (-0.81) HK13 (-0.44) HK14 (-2.14) HK15 (-1.22) HK16 (-0.45) HK18 (-0.18) HK19 (-1.40) HK20 (-1.57) HK21 (-0.28) HK22 (-0.10) HK24 (-0.94) HK27 (-0.26) HK28 (-1.38) HK29 (-1.74) HK31 (-0.73) HK33 (-0.15) HK36 (-0.90) HK37 (-0.06) HK38 (0.32) HK39 (0.00) HK42 (-2.31) HK46 (-1.62) HK47 (-0.25) HK49 (-0.47) HK62 (-0.59) HK63 (-0.06) HK64 (-1.80) HK67 (-0.51) HK84 (-4.16) HK85 (-0.20) SF1 (0.00) SF12 (-0.61) SF15 (0.82) SF17 (-1.23) SF18 (-1.77) SF21 (-0.32) SF22 (-2.23) SF23 (0.04) SF32 (-1.03) SF34 (-0.79) SF35 (-1.78) SF3 (-1.58) SF30 (-0.96) HK2 (-1.49) HK23 (0.10) HK41 (-0.77) SF4 (-1.43) SF8 (-0.57) SF9 (-1.97)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).