OncoDB.HCC Expression View

Gene name : EGFR
Ensembl ID ENSG00000146648
Description Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1). [Source:Uniprot/SWISSPROT;Acc:P00533]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
26 percent with 2 folds change ( 4 up and 11 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
Links Entrez Gene     Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 7 from 50054219 bp to 60242524 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 137017 -- IMAGE clone locate on exon ( blastn )
324861 -- IMAGE clone locate on exon ( tblastx )
669485 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.88) HK1 (-1.79) HK3 (0.06) HK4 (-1.93) HK5 (-2.26) HK7 (0.04) HK9 (0.61) HK11 (-1.01) HK12 (-0.33) HK13 (0.26) HK14 (-0.51) HK15 (0.03) HK16 (-0.98) HK18 (0.34) HK19 (-0.13) HK20 (0.84) HK21 (-0.50) HK22 (0.19) HK24 (-0.33) HK27 (-1.48) HK28 (-1.00) HK29 (0.38) HK31 (0.28) HK33 (-0.32) HK36 (0.49) HK37 (0.12) HK38 (1.17) HK39 (-0.67) HK42 (-0.09) HK46 (-1.62) HK47 (-0.59) HK49 (-0.12) HK62 (-0.34) HK63 (0.15) HK64 (-0.06) HK67 (0.52) HK84 (-0.60) HK85 (0.23) SF1 (-0.65) SF12 (-1.78) SF15 (0.09) SF17 (1.52) SF18 (-1.28) SF21 (-0.73) SF22 (0.15) SF23 (0.82) SF32 (0.21) SF34 (1.07) SF35 (-1.99) SF3 (-1.61) SF30 (0.20) HK2 (-0.28) HK23 (0.85) HK41 (0.25) SF4 (0.51) SF8 (-0.30) SF9 (-0.54)