OncoDB.HCC Expression View

Gene name : IGFBP3
Ensembl ID ENSG00000146674
Description Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3). [Source:Uniprot/SWISSPROT;Acc:P17936]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
82 percent with 2 folds change ( 1 up and 46 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- Northern    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 7 from 40918375 bp to 50927396 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 898218 -- IMAGE clone locate on exon ( tblastx )
CH2 (-4.05) HK1 (-2.15) HK3 (-2.35) HK4 (-1.66) HK5 (-1.89) HK7 (-3.22) HK9 (-2.90) HK11 (-0.18) HK12 (-3.08) HK13 (-0.84) HK14 (-0.82) HK15 (-1.52) HK16 (-2.09) HK18 (-2.75) HK19 (0.26) HK20 (-2.93) HK21 (-1.16) HK22 (-0.55) HK24 (-1.83) HK27 (-1.92) HK28 (-1.42) HK29 (-2.77) HK31 (-2.70) HK33 (-2.04) HK36 (-1.27) HK37 (-1.57) HK38 (-1.20) HK39 (-1.39) HK42 (2.88) HK46 (-3.90) HK47 (-2.36) HK49 (-1.54) HK62 (-0.29) HK63 (-3.11) HK64 (-2.14) HK67 (-2.69) HK84 (-2.81) HK85 (-1.11) SF1 (-1.55) SF12 (-1.78) SF15 (-0.67) SF17 (-4.17) SF18 (-2.64) SF21 (-1.29) SF22 (-1.42) SF23 (-1.25) SF32 (-2.42) SF34 (-1.85) SF35 (-0.25) SF3 (0.36) SF30 (-0.51) HK2 (-3.23) HK23 (-2.60) HK41 (-1.75) SF4 (-3.46) SF8 (-2.28) SF9 (-1.55)