OncoDB.HCC Expression View

Gene name : IGFBP1
Ensembl ID ENSG00000146678
Description Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12). [Source:Uniprot/SWISSPROT;Acc:P08833]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
68 percent with 2 folds change ( 3 up and 36 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Northern    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 7 from 40894484 bp to 50899791 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 491504 -- IMAGE clone locate on exon ( tblastx )
668685 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.01) HK1 (-1.02) HK3 (-3.17) HK4 (-3.13) HK5 (0.90) HK7 (-5.04) HK9 (-2.36) HK11 (-1.43) HK12 (-2.58) HK13 (-2.50) HK14 (-1.53) HK15 (-2.66) HK16 (-2.62) HK18 (-2.04) HK19 (0.18) HK20 (-1.83) HK21 (0.86) HK22 (-0.43) HK24 (-0.49) HK27 (-1.79) HK28 (-0.15) HK29 (-2.66) HK31 (-2.73) HK33 (1.81) HK36 (-1.50) HK37 (-0.46) HK38 (-0.59) HK39 (-1.40) HK42 (-2.18) HK46 (-1.20) HK47 (2.15) HK49 (0.07) HK62 (-0.22) HK63 (-1.63) HK64 (-3.65) HK67 (-0.04) HK84 (-2.46) HK85 (-0.40) SF1 (-0.26) SF12 (-2.36) SF15 (0.34) SF17 (0.25) SF18 (-1.43) SF21 (-1.46) SF22 (-1.09) SF23 (0.17) SF32 (-1.67) SF34 (-1.40) SF35 (-3.07) SF3 (0.56) SF30 (-4.13) HK2 (-1.30) HK23 (-1.14) HK41 (3.34) SF4 (-1.19) SF8 (-1.14) SF9 (0.40)