OncoDB.HCC Expression View

Gene name : GPC3
Ensembl ID ENSG00000147257
Description Glypican-3 precursor (Intestinal protein OCI-5) (GTR2-2) (MXR7). [Source:Uniprot/SWISSPROT;Acc:P51654]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
91 percent with 2 folds change ( 37 up and 15 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Northern, RT-PCR, IHC, QPCR, ISH    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr X from 127497439 bp to 137947588 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 878564 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.21) HK1 (1.18) HK3 (0.29) HK4 (-4.09) HK5 (1.26) HK7 (1.75) HK9 (7.19) HK11 (-3.21) HK12 (5.61) HK13 (0.00) HK14 (5.63) HK15 (3.89) HK16 (2.02) HK18 (13.47) HK19 (6.76) HK20 (11.23) HK21 (-0.37) HK22 (6.75) HK24 (5.90) HK27 (5.04) HK28 (9.38) HK29 (-5.21) HK31 (-6.92) HK33 (0.93) HK36 (-11.07) HK37 (5.13) HK38 (-3.49) HK39 (8.23) HK42 (6.27) HK46 (5.37) HK47 (9.23) HK49 (4.54) HK62 (1.56) HK63 (-3.98) HK64 (6.22) HK67 (7.68) HK84 (8.50) HK85 (-2.39) SF1 (-9.40) SF12 (10.15) SF15 (3.65) SF17 (0.11) SF18 (8.55) SF21 (-12.85) SF22 (-9.03) SF23 (1.44) SF32 (2.46) SF34 (-4.94) SF35 (-5.54) SF3 (-6.38) SF30 (6.61) HK2 (5.12) HK23 (3.85) HK41 (2.98) SF4 (3.18) SF8 (6.10) SF9 (6.03)