OncoDB.HCC Expression View

Gene name : CDKN2A
Ensembl ID ENSG00000147889
Description Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1). [Source:Uniprot/SWISSPROT;Acc:P42771]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
27 percent with 2 folds change ( 5 up and 10 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up/down     Method -- QPCR, RT-PCR, IHC, Western, Methylation, Mutation,    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 9 from 16957751 bp to 26984490 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1161155 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.12) HK1 (-1.31) HK3 (-0.74) HK4 (-1.68) HK5 (-1.12) HK7 (0.49) HK9 (0.00) HK11 (0.22) HK12 (0.35) HK13 (0.26) HK14 (0.24) HK15 (0.81) HK16 (-0.65) HK18 (-1.21) HK19 (-0.25) HK20 (0.21) HK21 (-0.30) HK22 (0.70) HK24 (-0.12) HK27 (-0.75) HK28 (-1.47) HK29 (0.24) HK31 (-1.14) HK33 (-0.53) HK36 (-1.06) HK37 (0.00) HK38 (1.00) HK39 (-0.14) HK42 (0.15) HK46 (-0.53) HK47 (0.00) HK49 (0.40) HK62 (-0.10) HK63 (-0.28) HK64 (0.55) HK67 (-0.53) HK84 (-0.63) HK85 (-0.36) SF1 (-0.36) SF12 (-0.05) SF15 (-0.22) SF17 (-1.20) SF18 (1.17) SF21 (-1.05) SF22 (3.23) SF23 (-0.39) SF32 (2.23) SF34 (0.21) SF35 (0.01) SF3 (-0.65) SF30 (-0.03) HK2 (-0.60) HK23 (0.18) HK41 (-1.55) SF4 (2.46) SF8 (0.30) SF9 (-0.15)