OncoDB.HCC Expression View

Gene name : LCN2
Ensembl ID ENSG00000148346
Description Neutrophil gelatinase-associated lipocalin precursor (NGAL) (p25) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3). [Source:Uniprot/SWISSPROT;Acc:P80188]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
68 percent with 2 folds change ( 27 up and 8 down in 51 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR, RT-PCR, ISH    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 9 from 124951171 bp to 134955555 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 741497 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (2.30) HK3 (-0.62) HK4 (2.28) HK5 (3.46) HK7 (-0.60) HK9 (0.00) HK11 (3.26) HK12 (-1.47) HK13 (0.06) HK14 (2.73) HK15 (1.43) HK16 (5.97) HK18 (2.61) HK19 (-1.78) HK20 (-0.75) HK21 (2.56) HK22 (0.63) HK24 (1.53) HK27 (4.05) HK28 (-2.86) HK29 (-2.33) HK31 (-0.74) HK33 (0.38) HK36 (0.09) HK37 (1.39) HK38 (6.20) HK39 (2.52) HK42 (-1.67) HK46 (4.36) HK47 (0.00) HK49 (-0.35) HK62 (2.20) HK63 (0.72) HK64 (-0.69) HK67 (1.44) HK84 (-0.44) HK85 (2.26) SF1 (4.04) SF12 (-1.29) SF15 (4.00) SF17 (2.27) SF18 (5.11) SF21 (0.01) SF22 (0.00) SF23 (-1.75) SF32 (0.00) SF34 (-2.16) SF35 (2.02) SF3 (0.00) SF30 (2.00) HK2 (0.42) HK23 (1.01) HK41 (0.72) SF4 (1.07) SF8 (3.38) SF9 (0.17)