OncoDB.HCC Expression View

Gene name : ITGB1
Ensembl ID ENSG00000150093
Description Integrin beta-1 precursor (Fibronectin receptor subunit beta) (Integrin VLA-4 subunit beta) (CD29 antigen). [Source:Uniprot/SWISSPROT;Acc:P05556]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
19 percent with 2 folds change ( 11 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 10 from 28229326 bp to 38287204 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 325953 -- IMAGE clone locate on exon ( blastn )
343072 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.71) HK1 (0.71) HK3 (0.70) HK4 (0.50) HK5 (0.07) HK7 (-0.16) HK9 (-0.02) HK11 (1.26) HK12 (0.83) HK13 (0.62) HK14 (0.19) HK15 (0.25) HK16 (-0.66) HK18 (-0.45) HK19 (0.30) HK20 (1.09) HK21 (1.52) HK22 (-0.23) HK24 (0.60) HK27 (-0.41) HK28 (-0.12) HK29 (-0.24) HK31 (1.25) HK33 (0.00) HK36 (0.93) HK37 (0.89) HK38 (0.84) HK39 (-0.02) HK42 (-0.50) HK46 (0.05) HK47 (0.77) HK49 (1.00) HK62 (-0.59) HK63 (-0.68) HK64 (1.60) HK67 (0.78) HK84 (0.46) HK85 (-0.29) SF1 (-0.51) SF12 (1.16) SF15 (1.02) SF17 (1.25) SF18 (-0.13) SF21 (0.44) SF22 (0.58) SF23 (-0.92) SF32 (0.70) SF34 (-0.06) SF35 (0.69) SF3 (0.15) SF30 (-0.16) HK2 (0.75) HK23 (0.66) HK41 (-0.39) SF4 (0.67) SF8 (1.09) SF9 (0.72)