OncoDB.HCC Expression View

Gene name : GPM6A
Ensembl ID ENSG00000150625
Description Neuronal membrane glycoprotein M6-a (M6a). [Source:Uniprot/SWISSPROT;Acc:P51674]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
82 percent with 2 folds change ( 0 up and 42 down in 51 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 171791083 bp to 182160642 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 784910 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.94) HK1 (-2.61) HK3 (-1.79) HK4 (-1.47) HK5 (-0.87) HK7 (-3.07) HK9 (-1.71) HK11 (0.00) HK12 (-0.75) HK13 (-1.31) HK14 (-1.29) HK15 (-2.16) HK16 (-1.25) HK18 (-2.20) HK19 (-2.18) HK20 (-1.75) HK21 (-1.32) HK22 (-1.92) HK24 (-2.19) HK27 (-1.25) HK28 (-1.51) HK29 (-1.37) HK31 (0.00) HK33 (-2.47) HK36 (-2.00) HK37 (-2.18) HK38 (-2.34) HK39 (0.00) HK42 (0.00) HK46 (-2.23) HK47 (-1.71) HK49 (-1.26) HK62 (-0.06) HK63 (-6.48) HK64 (-1.84) HK67 (-2.76) HK84 (0.00) HK85 (-4.36) SF1 (-2.27) SF12 (-1.99) SF15 (-0.66) SF17 (-0.98) SF18 (-1.15) SF21 (0.88) SF22 (-0.82) SF23 (-0.93) SF32 (-1.08) SF34 (0.00) SF35 (-1.63) SF3 (-3.32) SF30 (-2.36) HK2 (-2.55) HK23 (-2.49) HK41 (0.00) SF4 (-1.17) SF8 (-1.35) SF9 (-2.15)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).