OncoDB.HCC Expression View

Gene name : ACSL1
Ensembl ID ENSG00000151726
Description Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase 1) (Long-chain fatty acid CoA ligase 2) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Acyl-CoA synthetase 1) (ACS1) (Palmitoyl-CoA ligase 2). [Source:Uniprot/SWISSPROT;Acc:P33121]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
49 percent with 2 folds change ( 2 up and 25 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene    
Display nearby genome region Chr 4 from 180913744 bp to 190984209 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 82734 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.39) HK1 (-1.05) HK3 (-1.42) HK4 (-2.86) HK5 (-0.77) HK7 (-0.01) HK9 (-0.07) HK11 (-1.35) HK12 (-1.56) HK13 (-0.10) HK14 (-2.96) HK15 (-1.57) HK16 (-0.24) HK18 (-0.45) HK19 (0.26) HK20 (-0.99) HK21 (-2.35) HK22 (1.34) HK24 (-1.36) HK27 (-1.85) HK28 (0.32) HK29 (-1.13) HK31 (-0.17) HK33 (-0.58) HK36 (-0.16) HK37 (-2.85) HK38 (-2.37) HK39 (1.09) HK42 (-1.79) HK46 (-0.63) HK47 (-3.58) HK49 (-0.76) HK62 (-0.77) HK63 (0.03) HK64 (-1.55) HK67 (-0.46) HK84 (0.00) HK85 (0.59) SF1 (-0.82) SF12 (-2.34) SF15 (0.24) SF17 (-0.48) SF18 (-2.94) SF21 (0.46) SF22 (-0.42) SF23 (-0.07) SF32 (0.85) SF34 (0.00) SF35 (-1.49) SF3 (0.79) SF30 (-2.45) HK2 (-1.86) HK23 (-2.79) HK41 (-1.12) SF4 (-1.30) SF8 (-0.71) SF9 (-4.57)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).