OncoDB.HCC Expression View

Gene name : TDO2
Ensembl ID ENSG00000151790
Description Tryptophan 2,3-dioxygenase (EC 1.13.11.11) (TO) (Tryptophan pyrrolase) (Tryptophanase) (Tryptophan oxygenase) (Tryptamin 2,3-dioxygenase) (TRPO). [Source:Uniprot/SWISSPROT;Acc:P48775]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
53 percent with 2 folds change ( 5 up and 23 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 152044297 bp to 162061000 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 86220 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.80) HK1 (-1.43) HK3 (-1.90) HK4 (-4.43) HK5 (-1.07) HK7 (3.02) HK9 (-5.74) HK11 (-1.05) HK12 (-1.44) HK13 (0.00) HK14 (0.00) HK15 (0.00) HK16 (-0.86) HK18 (-0.27) HK19 (0.57) HK20 (-1.11) HK21 (-1.65) HK22 (0.36) HK24 (-3.88) HK27 (-0.32) HK28 (-0.06) HK29 (0.37) HK31 (1.17) HK33 (0.64) HK36 (0.14) HK37 (-1.27) HK38 (1.40) HK39 (-0.06) HK42 (-3.21) HK46 (0.00) HK47 (-2.55) HK49 (0.31) HK62 (0.52) HK63 (-0.18) HK64 (-3.10) HK67 (-1.45) HK84 (-0.67) HK85 (-1.54) SF1 (0.40) SF12 (-3.19) SF15 (-3.87) SF17 (0.71) SF18 (-0.22) SF21 (0.33) SF22 (-1.37) SF23 (-4.09) SF32 (2.35) SF34 (-0.40) SF35 (-0.94) SF3 (0.63) SF30 (3.67) HK2 (0.00) HK23 (-2.14) HK41 (-1.06) SF4 (0.58) SF8 (-0.28) SF9 (-2.12)