OncoDB.HCC Expression View

Gene name : NAT2
Ensembl ID ENSG00000156006
Description Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Source:Uniprot/SWISSPROT;Acc:P11245]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
89 percent with 2 folds change ( 2 up and 39 down in 46 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene    
Display nearby genome region Chr 8 from 13293035 bp to 23302962 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1870937 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-1.31) HK3 (-4.54) HK4 (-2.76) HK5 (-2.23) HK7 (0.00) HK9 (-4.62) HK11 (-4.11) HK12 (-2.20) HK13 (0.00) HK14 (-6.68) HK15 (0.00) HK16 (0.47) HK18 (-2.25) HK19 (0.00) HK20 (-2.54) HK21 (-3.19) HK22 (-1.07) HK24 (-4.58) HK27 (-5.40) HK28 (-3.81) HK29 (-2.86) HK31 (-2.19) HK33 (-3.58) HK36 (-4.12) HK37 (-6.05) HK38 (-6.11) HK39 (-6.50) HK42 (0.00) HK46 (-2.34) HK47 (0.00) HK49 (0.00) HK62 (-2.31) HK63 (-2.90) HK64 (-2.42) HK67 (-4.76) HK84 (0.00) HK85 (0.00) SF1 (-2.50) SF12 (-6.19) SF15 (-1.80) SF17 (1.50) SF18 (-6.07) SF21 (-3.89) SF22 (0.00) SF23 (-0.88) SF32 (1.21) SF34 (-0.29) SF35 (-3.78) SF3 (-4.28) SF30 (-5.11) HK2 (-1.44) HK23 (-2.85) HK41 (0.22) SF4 (-1.78) SF8 (-0.75) SF9 (-7.96)