OncoDB.HCC Expression View

Gene name : DCK
Ensembl ID ENSG00000156136
Description Deoxycytidine kinase (EC 2.7.1.74) (dCK). [Source:Uniprot/SWISSPROT;Acc:P27707]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
15 percent with 2 folds change ( 8 up and 1 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 67078256 bp to 77115477 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 43198 -- IMAGE clone locate on exon ( tblastx )
786194 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.41) HK1 (0.71) HK3 (0.60) HK4 (0.50) HK5 (0.15) HK7 (1.08) HK9 (0.59) HK11 (0.86) HK12 (-0.03) HK13 (0.97) HK14 (1.40) HK15 (-0.04) HK16 (0.37) HK18 (0.74) HK19 (-0.08) HK20 (0.16) HK21 (0.94) HK22 (0.47) HK24 (0.25) HK27 (1.03) HK28 (-0.05) HK29 (0.34) HK31 (0.41) HK33 (-0.01) HK36 (0.39) HK37 (1.40) HK38 (0.61) HK39 (0.63) HK42 (0.82) HK46 (0.79) HK47 (0.37) HK49 (0.57) HK62 (0.50) HK63 (-0.27) HK64 (0.22) HK67 (0.81) HK84 (0.75) HK85 (2.03) SF1 (0.99) SF12 (1.60) SF15 (0.69) SF17 (-0.02) SF18 (-0.37) SF21 (0.02) SF22 (-0.07) SF23 (-0.02) SF32 (-0.17) SF34 (0.71) SF35 (1.09) SF3 (0.95) SF30 (0.95) HK2 (-1.06) HK23 (0.30) HK41 (0.80) SF4 (0.89) SF8 (0.56) SF9 (1.20)