OncoDB.HCC Expression View

Gene name : SMG1_HUMAN
Ensembl ID ENSG00000157106
Description Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4). [Source:Uniprot/SWISSPROT;Acc:Q96Q15]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
77 percent with 2 folds change ( 1 up and 43 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 16 from 13723677 bp to 23845239 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 200395 -- IMAGE clone locate on exon ( tblastx )
261580 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.95) HK1 (-3.29) HK3 (-2.60) HK4 (-2.57) HK5 (-4.19) HK7 (-2.63) HK9 (-2.08) HK11 (-2.04) HK12 (-1.52) HK13 (-1.91) HK14 (-2.18) HK15 (-2.16) HK16 (-1.85) HK18 (-1.23) HK19 (-2.73) HK20 (-1.45) HK21 (-1.34) HK22 (-0.93) HK24 (-1.38) HK27 (-3.35) HK28 (-1.70) HK29 (-0.90) HK31 (-0.71) HK33 (-3.62) HK36 (-2.43) HK37 (-0.13) HK38 (-1.86) HK39 (-3.41) HK42 (-4.10) HK46 (-2.53) HK47 (-1.59) HK49 (-3.57) HK62 (-0.80) HK63 (-1.48) HK64 (-1.71) HK67 (-0.58) HK84 (-0.92) HK85 (-1.09) SF1 (-0.64) SF12 (-0.90) SF15 (0.31) SF17 (0.39) SF18 (-1.85) SF21 (-1.40) SF22 (-2.37) SF23 (-0.49) SF32 (1.12) SF34 (-4.00) SF35 (-3.61) SF3 (-1.00) SF30 (-3.25) HK2 (-2.36) HK23 (-2.38) HK41 (-3.52) SF4 (-3.51) SF8 (0.03) SF9 (-2.15)