OncoDB.HCC Expression View

Gene name : MMP14
Ensembl ID ENSG00000157227
Description Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1). [Source:Uniprot/SWISSPROT;Acc:P50281]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
52 percent with 2 folds change ( 1 up and 27 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- ISH    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 14 from 17375676 bp to 27385088 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 270505 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.23) HK3 (-2.15) HK4 (-0.25) HK5 (0.00) HK7 (0.30) HK9 (-4.95) HK11 (-0.87) HK12 (0.09) HK13 (0.15) HK14 (0.95) HK15 (-0.62) HK16 (-1.38) HK18 (-1.78) HK19 (-0.28) HK20 (-1.68) HK21 (0.70) HK22 (-0.86) HK24 (-1.25) HK27 (0.33) HK28 (-1.25) HK29 (-2.27) HK31 (-0.88) HK33 (-1.35) HK36 (0.05) HK37 (0.67) HK38 (-0.07) HK39 (-0.20) HK42 (-0.14) HK46 (-1.14) HK47 (-4.28) HK49 (-0.41) HK62 (-2.51) HK63 (-1.57) HK64 (-0.71) HK67 (0.00) HK84 (-1.09) HK85 (-2.46) SF1 (-1.00) SF12 (-0.58) SF15 (-1.09) SF17 (-1.68) SF18 (1.59) SF21 (-0.35) SF22 (-2.47) SF23 (-0.95) SF32 (0.00) SF34 (-0.54) SF35 (-2.12) SF3 (-2.82) SF30 (-1.21) HK2 (-1.28) HK23 (-2.58) HK41 (-2.67) SF4 (-1.45) SF8 (-3.15) SF9 (0.95)