OncoDB.HCC Expression View

Gene name : HPD
Ensembl ID ENSG00000158104
Description 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4HPPD) (HPD) (HPPDase) (4-hydroxyphenylpyruvic acid oxidase). [Source:Uniprot/SWISSPROT;Acc:P32754]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
64 percent with 2 folds change ( 7 up and 28 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 12 from 115761818 bp to 125781152 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 430314 -- IMAGE clone locate on exon ( blastn )
CH2 (0.86) HK1 (-0.45) HK3 (-0.89) HK4 (-1.11) HK5 (2.11) HK7 (1.63) HK9 (-5.91) HK11 (-4.53) HK12 (-2.92) HK13 (-1.63) HK14 (-5.84) HK15 (-1.21) HK16 (0.20) HK18 (-0.18) HK19 (-3.40) HK20 (-1.56) HK21 (-2.31) HK22 (0.81) HK24 (0.14) HK27 (0.00) HK28 (0.53) HK29 (-0.29) HK31 (-0.23) HK33 (1.03) HK36 (1.35) HK37 (0.00) HK38 (-4.82) HK39 (-7.00) HK42 (-2.34) HK46 (-2.35) HK47 (-5.08) HK49 (-1.53) HK62 (-0.66) HK63 (-3.92) HK64 (-1.31) HK67 (-2.21) HK84 (-1.85) HK85 (-3.50) SF1 (0.32) SF12 (-4.11) SF15 (-0.94) SF17 (0.98) SF18 (0.00) SF21 (0.32) SF22 (6.55) SF23 (-0.22) SF32 (0.50) SF34 (1.53) SF35 (-4.61) SF3 (-4.14) SF30 (-5.24) HK2 (-4.30) HK23 (-1.15) HK41 (0.73) SF4 (1.87) SF8 (-0.57) SF9 (-6.41)