OncoDB.HCC Expression View

Gene name : PSMD4
Ensembl ID ENSG00000159352
Description 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit S5A) (Rpn10) (Multiubiquitin chain-binding protein) (Antisecretory factor 1) (AF) (ASF). [Source:Uniprot/SWISSPROT;Acc:P55036]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
17 percent with 2 folds change ( 10 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Northern    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 144493803 bp to 154506579 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 789232 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.41) HK1 (1.39) HK3 (0.94) HK4 (1.64) HK5 (0.79) HK7 (0.34) HK9 (-0.23) HK11 (0.44) HK12 (0.59) HK13 (0.52) HK14 (0.43) HK15 (1.41) HK16 (0.90) HK18 (0.53) HK19 (1.25) HK20 (-0.03) HK21 (0.81) HK22 (0.40) HK24 (0.65) HK27 (1.60) HK28 (0.14) HK29 (0.47) HK31 (0.82) HK33 (0.38) HK36 (1.12) HK37 (-0.08) HK38 (0.53) HK39 (0.49) HK42 (0.49) HK46 (0.94) HK47 (1.05) HK49 (0.56) HK62 (-0.23) HK63 (-0.10) HK64 (0.67) HK67 (0.03) HK84 (0.46) HK85 (-0.54) SF1 (-0.47) SF12 (0.97) SF15 (0.45) SF17 (1.11) SF18 (0.40) SF21 (0.98) SF22 (1.39) SF23 (0.08) SF32 (-0.10) SF34 (-0.26) SF35 (0.37) SF3 (0.52) SF30 (0.95) HK2 (0.91) HK23 (0.15) HK41 (1.40) SF4 (0.61) SF8 (0.90) SF9 (0.45)