OncoDB.HCC Expression View

Gene name : ALDH4A1
Ensembl ID ENSG00000159423
Description Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor (EC 1.5.1.12) (P5C dehydrogenase) (Aldehyde dehydrogenase 4A1). [Source:Uniprot/SWISSPROT;Acc:P30038]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
21 percent with 2 folds change ( 0 up and 12 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 14070513 bp to 24101862 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 47853 -- IMAGE clone locate on exon ( blastn )
CH2 (-0.25) HK1 (-0.19) HK3 (-2.36) HK4 (-0.11) HK5 (0.23) HK7 (0.63) HK9 (-0.76) HK11 (-1.86) HK12 (-0.64) HK13 (-0.07) HK14 (-0.43) HK15 (-0.30) HK16 (0.82) HK18 (-0.24) HK19 (-0.06) HK20 (0.42) HK21 (-1.92) HK22 (0.25) HK24 (-0.16) HK27 (-3.24) HK28 (-0.48) HK29 (-0.33) HK31 (-0.46) HK33 (-0.08) HK36 (-0.94) HK37 (-0.46) HK38 (-1.09) HK39 (-2.56) HK42 (0.18) HK46 (-0.31) HK47 (-4.44) HK49 (-0.44) HK62 (-0.18) HK63 (-0.35) HK64 (-0.77) HK67 (-0.60) HK84 (-0.24) HK85 (-0.59) SF1 (-0.12) SF12 (-0.50) SF15 (-1.17) SF17 (0.57) SF18 (-0.77) SF21 (-0.13) SF22 (0.77) SF23 (-0.19) SF32 (-0.64) SF34 (0.83) SF35 (-0.62) SF3 (-0.02) SF30 (-2.90) HK2 (-0.40) HK23 (-2.03) HK41 (-2.30) SF4 (-0.03) SF8 (0.89) SF9 (-1.39)