OncoDB.HCC Expression View

Gene name : CBS
Ensembl ID ENSG00000160200
Description Cystathionine beta-synthase (EC 4.2.1.22) (Serine sulfhydrase) (Beta- thionase). [Source:Uniprot/SWISSPROT;Acc:P35520]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 4 up and 25 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 21 from 38346374 bp to 46944323 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 769857 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.61) HK1 (-2.08) HK3 (-0.24) HK4 (-1.79) HK5 (-1.03) HK7 (0.75) HK9 (-0.85) HK11 (-3.03) HK12 (-1.99) HK13 (-0.47) HK14 (-3.37) HK15 (0.63) HK16 (-0.42) HK18 (-0.09) HK19 (-0.13) HK20 (0.46) HK21 (-1.71) HK22 (0.27) HK24 (0.15) HK27 (-2.47) HK28 (-0.11) HK29 (-1.29) HK31 (1.43) HK33 (1.12) HK36 (-0.70) HK37 (-1.00) HK38 (-0.84) HK39 (-1.69) HK42 (-0.19) HK46 (-1.22) HK47 (-1.27) HK49 (-1.65) HK62 (0.17) HK63 (-0.10) HK64 (0.63) HK67 (-1.51) HK84 (-0.45) HK85 (-0.66) SF1 (-0.88) SF12 (-2.29) SF15 (-1.78) SF17 (0.36) SF18 (-3.42) SF21 (-1.42) SF22 (-0.41) SF23 (1.36) SF32 (-0.39) SF34 (1.24) SF35 (-2.00) SF3 (-0.23) SF30 (-3.88) HK2 (-1.70) HK23 (0.63) HK41 (-0.14) SF4 (0.00) SF8 (-1.51) SF9 (-1.44)