OncoDB.HCC Expression View

Gene name : FTCD
Ensembl ID ENSG00000160282
Description Formimidoyltransferase-cyclodeaminase (Formiminotransferase- cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase [Source:Uniprot/SWISSPROT;Acc:O95954]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
57 percent with 2 folds change ( 3 up and 30 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 21 from 41380605 bp to 46944323 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 296498 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.00) HK1 (-1.05) HK3 (-2.30) HK4 (-2.55) HK5 (-0.57) HK7 (0.75) HK9 (-0.72) HK11 (-2.29) HK12 (-1.23) HK13 (-1.09) HK14 (-2.03) HK15 (-2.17) HK16 (-1.05) HK18 (-0.89) HK19 (-0.64) HK20 (-1.20) HK21 (-1.42) HK22 (0.77) HK24 (-0.81) HK27 (-1.39) HK28 (0.23) HK29 (0.37) HK31 (-0.41) HK33 (0.22) HK36 (0.61) HK37 (-2.16) HK38 (-1.34) HK39 (-0.95) HK42 (-2.52) HK46 (-2.17) HK47 (-4.06) HK49 (0.28) HK62 (1.06) HK63 (-2.08) HK64 (-1.81) HK67 (-0.96) HK84 (-0.68) HK85 (1.13) SF1 (-0.52) SF12 (-1.58) SF15 (-1.91) SF17 (-0.49) SF18 (-1.81) SF21 (0.23) SF22 (0.82) SF23 (-0.08) SF32 (-4.21) SF34 (1.25) SF35 (-3.53) SF3 (-2.93) SF30 (-3.58) HK2 (-0.27) HK23 (-1.55) HK41 (-1.50) SF4 (-0.56) SF8 (-1.05) SF9 (-1.79)