OncoDB.HCC Expression View

Gene name : SHC1
Ensembl ID ENSG00000160691
Description SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1). [Source:Uniprot/SWISSPROT;Acc:P29353]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
53 percent with 2 folds change ( 26 up and 4 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 148201398 bp to 158213476 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 40303 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.60) HK1 (1.92) HK3 (0.73) HK4 (1.64) HK5 (1.38) HK7 (2.51) HK9 (0.79) HK11 (1.31) HK12 (1.02) HK13 (2.29) HK14 (1.91) HK15 (2.96) HK16 (-0.01) HK18 (0.98) HK19 (0.90) HK20 (0.67) HK21 (1.05) HK22 (0.09) HK24 (0.07) HK27 (0.80) HK28 (-1.34) HK29 (1.00) HK31 (0.65) HK33 (-1.22) HK36 (2.77) HK37 (0.40) HK38 (2.53) HK39 (1.80) HK42 (-0.80) HK46 (0.72) HK47 (-2.38) HK49 (1.07) HK62 (0.58) HK63 (0.57) HK64 (2.11) HK67 (0.99) HK84 (1.60) HK85 (-0.76) SF1 (1.81) SF12 (0.28) SF15 (3.04) SF17 (0.88) SF18 (-0.37) SF21 (0.82) SF22 (0.00) SF23 (-1.12) SF32 (1.07) SF34 (-0.12) SF35 (0.55) SF3 (1.95) SF30 (2.40) HK2 (1.46) HK23 (0.93) HK41 (0.53) SF4 (2.40) SF8 (1.90) SF9 (0.80)