OncoDB.HCC Expression View

Gene name : FDPS
Ensembl ID ENSG00000160752
Description Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)]. [Source:Uniprot/SWISSPROT;Acc:P14324]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
75 percent with 2 folds change ( 43 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 148545267 bp to 158557080 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 80410 -- IMAGE clone locate on exon ( blastn )
CH2 (1.60) HK1 (2.61) HK3 (1.62) HK4 (1.71) HK5 (2.14) HK7 (1.46) HK9 (2.08) HK11 (1.26) HK12 (2.09) HK13 (2.24) HK14 (2.24) HK15 (2.40) HK16 (1.51) HK18 (0.68) HK19 (2.91) HK20 (0.98) HK21 (0.39) HK22 (-0.08) HK24 (1.80) HK27 (2.92) HK28 (2.08) HK29 (1.30) HK31 (1.27) HK33 (2.28) HK36 (0.29) HK37 (1.26) HK38 (0.94) HK39 (2.42) HK42 (1.75) HK46 (2.19) HK47 (4.80) HK49 (1.03) HK62 (1.35) HK63 (2.48) HK64 (1.16) HK67 (1.27) HK84 (2.52) HK85 (0.88) SF1 (1.42) SF12 (1.19) SF15 (-0.89) SF17 (0.09) SF18 (2.02) SF21 (-0.31) SF22 (2.17) SF23 (-0.32) SF32 (1.81) SF34 (1.52) SF35 (2.00) SF3 (2.38) SF30 (0.71) HK2 (1.42) HK23 (1.28) HK41 (1.55) SF4 (0.11) SF8 (-0.25) SF9 (1.05)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).