OncoDB.HCC Expression View

Gene name : PRPSAP1
Ensembl ID ENSG00000161542
Description Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPP synthetase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP39). [Source:Uniprot/SWISSPROT;Acc:Q14558]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
29 percent with 2 folds change ( 16 up and 0 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 17 from 66818609 bp to 76861825 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 33949 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.62) HK1 (0.05) HK3 (0.22) HK4 (1.42) HK5 (-0.10) HK7 (1.47) HK9 (0.65) HK11 (0.75) HK12 (-0.05) HK13 (0.97) HK14 (0.89) HK15 (1.37) HK16 (0.75) HK18 (0.56) HK19 (0.10) HK20 (0.25) HK21 (0.11) HK22 (0.15) HK24 (0.61) HK27 (0.33) HK28 (2.29) HK29 (0.53) HK31 (1.30) HK33 (0.46) HK36 (0.17) HK37 (1.31) HK38 (0.17) HK39 (0.70) HK42 (2.65) HK46 (0.40) HK47 (1.65) HK49 (0.35) HK62 (1.00) HK63 (1.08) HK64 (1.61) HK67 (1.30) HK84 (0.00) HK85 (1.75) SF1 (2.52) SF12 (1.14) SF15 (0.62) SF17 (0.35) SF18 (-0.39) SF21 (-0.62) SF22 (0.34) SF23 (0.32) SF32 (0.66) SF34 (0.36) SF35 (0.51) SF3 (0.61) SF30 (1.20) HK2 (0.50) HK23 (0.00) HK41 (0.88) SF4 (-0.35) SF8 (0.39) SF9 (0.22)