OncoDB.HCC Expression View

Gene name : ALPL
Ensembl ID ENSG00000162551
Description Alkaline phosphatase, tissue-nonspecific isozyme precursor (EC 3.1.3.1) (AP-TNAP) (Liver/bone/kidney isozyme) (TNSALP). [Source:Uniprot/SWISSPROT;Acc:P05186]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
72 percent with 2 folds change ( 2 up and 38 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 1 from 16708452 bp to 26777492 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1475595 -- IMAGE clone locate on exon ( tblastx )
CH2 (-4.00) HK1 (-1.29) HK3 (-2.51) HK4 (-6.81) HK5 (0.25) HK7 (-1.25) HK9 (-0.64) HK11 (-1.79) HK12 (0.44) HK13 (-2.28) HK14 (-2.89) HK15 (-0.56) HK16 (-0.36) HK18 (-1.45) HK19 (-1.11) HK20 (-2.20) HK21 (-1.03) HK22 (0.78) HK24 (-1.11) HK27 (-1.76) HK28 (-2.07) HK29 (-1.23) HK31 (-2.62) HK33 (-1.93) HK36 (-0.34) HK37 (0.00) HK38 (0.12) HK39 (-1.85) HK42 (-0.91) HK46 (0.09) HK47 (-4.88) HK49 (-2.20) HK62 (-0.03) HK63 (-2.14) HK64 (-2.79) HK67 (-2.58) HK84 (-1.92) HK85 (0.00) SF1 (1.79) SF12 (-2.57) SF15 (-3.05) SF17 (0.66) SF18 (-0.87) SF21 (-0.38) SF22 (-1.57) SF23 (-1.62) SF32 (3.51) SF34 (-2.62) SF35 (-1.71) SF3 (-3.17) SF30 (-3.01) HK2 (-2.12) HK23 (-2.51) HK41 (-1.90) SF4 (-2.73) SF8 (-0.72) SF9 (-4.20)