OncoDB.HCC Expression View

Gene name : NCSTN
Ensembl ID ENSG00000162736
Description Nicastrin precursor. [Source:Uniprot/SWISSPROT;Acc:Q92542]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
55 percent with 2 folds change ( 31 up and 0 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, ISH    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 1 from 153579678 bp to 163595366 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 199645 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.28) HK1 (0.29) HK3 (1.36) HK4 (1.96) HK5 (0.75) HK7 (0.22) HK9 (1.22) HK11 (0.00) HK12 (1.10) HK13 (1.05) HK14 (1.35) HK15 (1.74) HK16 (1.39) HK18 (0.03) HK19 (0.61) HK20 (1.09) HK21 (0.64) HK22 (0.64) HK24 (0.50) HK27 (1.70) HK28 (0.37) HK29 (1.09) HK31 (0.61) HK33 (0.57) HK36 (-0.31) HK37 (0.24) HK38 (0.98) HK39 (1.81) HK42 (1.85) HK46 (0.85) HK47 (0.67) HK49 (1.14) HK62 (0.99) HK63 (1.26) HK64 (1.84) HK67 (0.65) HK84 (0.75) HK85 (0.87) SF1 (1.28) SF12 (1.96) SF15 (1.01) SF17 (1.70) SF18 (1.28) SF21 (1.14) SF22 (1.86) SF23 (0.14) SF32 (0.43) SF34 (1.05) SF35 (1.61) SF3 (1.15) SF30 (1.33) HK2 (1.34) HK23 (-0.10) HK41 (1.37) SF4 (0.88) SF8 (1.03) SF9 (0.30)