OncoDB.HCC Expression View

Gene name : HAAO
Ensembl ID ENSG00000162882
Description 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-HAO) (3- hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [Source:Uniprot/SWISSPROT;Acc:P46952]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
59 percent with 2 folds change ( 4 up and 28 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 2 from 37847736 bp to 47873238 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 109310 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.15) HK1 (-1.73) HK3 (-1.26) HK4 (-2.10) HK5 (-0.42) HK7 (2.30) HK9 (0.00) HK11 (-1.49) HK12 (0.37) HK13 (-1.12) HK14 (-3.39) HK15 (-2.17) HK16 (-0.03) HK18 (-0.92) HK19 (-1.52) HK20 (-0.62) HK21 (-2.22) HK22 (0.10) HK24 (-0.48) HK27 (-3.96) HK28 (-3.33) HK29 (-0.49) HK31 (0.29) HK33 (-0.32) HK36 (-0.69) HK37 (-3.45) HK38 (-1.57) HK39 (-0.84) HK42 (-0.81) HK46 (-1.03) HK47 (-6.03) HK49 (-3.65) HK62 (0.00) HK63 (-0.80) HK64 (-2.75) HK67 (0.33) HK84 (-5.46) HK85 (0.31) SF1 (-2.52) SF12 (-1.87) SF15 (-4.76) SF17 (1.18) SF18 (-2.32) SF21 (0.11) SF22 (2.91) SF23 (-2.16) SF32 (3.87) SF34 (0.25) SF35 (-0.89) SF3 (-2.46) SF30 (-1.36) HK2 (-0.86) HK23 (-0.90) HK41 (0.00) SF4 (-1.78) SF8 (-0.65) SF9 (-3.83)