OncoDB.HCC Expression View

Gene name : TGFBR2
Ensembl ID ENSG00000163513
Description TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TbetaR-II). [Source:Uniprot/SWISSPROT;Acc:P37173]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
12 percent with 2 folds change ( 2 up and 4 down in 50 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, Mutation    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 3 from 25622998 bp to 35710635 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 841149 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.13) HK1 (0.13) HK3 (-0.44) HK4 (0.52) HK5 (0.07) HK7 (-0.15) HK9 (0.00) HK11 (0.85) HK12 (-0.55) HK13 (-0.70) HK14 (-0.21) HK15 (-0.35) HK16 (0.65) HK18 (0.72) HK19 (0.17) HK20 (-1.43) HK21 (0.05) HK22 (-0.52) HK24 (-0.46) HK27 (-0.83) HK28 (-0.47) HK29 (-0.48) HK31 (0.35) HK33 (0.11) HK36 (0.30) HK37 (0.84) HK38 (0.79) HK39 (-0.09) HK42 (-0.48) HK46 (-0.25) HK47 (2.01) HK49 (0.80) HK62 (-0.08) HK63 (-1.60) HK64 (-0.76) HK67 (1.34) HK84 (-0.34) HK85 (0.94) SF1 (-0.18) SF12 (0.00) SF15 (0.00) SF17 (-0.74) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (-1.14) SF34 (0.10) SF35 (-0.18) SF3 (0.08) SF30 (-0.59) HK2 (-0.13) HK23 (0.14) HK41 (-0.53) SF4 (-0.29) SF8 (0.91) SF9 (0.71)