OncoDB.HCC Expression View

Gene name : DNASE1L3
Ensembl ID ENSG00000163687
Description Deoxyribonuclease gamma precursor (EC 3.1.21.-) (DNase gamma) (Deoxyribonuclease I-like 3) (DNase I homolog protein DHP2) (Liver and spleen DNase) (LS-DNase) (LSD). [Source:Uniprot/SWISSPROT;Acc:Q13609]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
86 percent with 2 folds change ( 3 up and 43 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 3 from 53153454 bp to 63175893 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 82738 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.67) HK1 (-2.00) HK3 (-2.89) HK4 (-5.76) HK5 (-0.20) HK7 (-4.57) HK9 (-1.88) HK11 (-2.83) HK12 (-1.77) HK13 (0.00) HK14 (-5.51) HK15 (-3.21) HK16 (0.00) HK18 (-2.26) HK19 (-3.05) HK20 (-2.17) HK21 (-2.28) HK22 (0.21) HK24 (-2.49) HK27 (-3.39) HK28 (-2.17) HK29 (-0.59) HK31 (-0.62) HK33 (-0.64) HK36 (-0.55) HK37 (-5.07) HK38 (-1.14) HK39 (0.00) HK42 (-3.14) HK46 (-4.79) HK47 (-4.22) HK49 (-2.25) HK62 (-1.43) HK63 (-2.82) HK64 (-4.47) HK67 (-1.44) HK84 (-3.00) HK85 (2.26) SF1 (-4.15) SF12 (-4.57) SF15 (-4.07) SF17 (1.03) SF18 (-5.31) SF21 (1.55) SF22 (-2.61) SF23 (-2.86) SF32 (-3.12) SF34 (0.43) SF35 (-2.45) SF3 (-3.41) SF30 (-4.29) HK2 (-2.33) HK23 (-3.30) HK41 (-1.84) SF4 (0.00) SF8 (-1.06) SF9 (-3.61)